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br Literature review br Design of the educator survey br
2018-10-29
Literature review Design of the educator survey Results and discussions Conclusions and recommendations Introduction As per ASHRAE 55 (RAA-C.E, 2013), thermal comfort is defined as “that condition of mind that expresses satisfaction with the thermal environment and is assessed by subj
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The brief preface of the
2018-10-29
The brief preface of the handbook explains who are the addressees: “This brochure is not made for cathedral builders. This is not even an essay on the famous uncouplers of oxidative phosphorylation of Chinese art in our Christian churches. Every missionary may come to be a builder, be it of a villag
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We report a rare case
2018-10-29
We report a rare case of complex distal fusiform RAA at the bifurcation of the left renal artery, for which endovascular intervention was not viable. Using hand-assisted laparoscopic nephrectomy combined with backbench repair and autotransplantation (which is a feasible, safe, and tolerable procedur
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The prognosis and treatment of
2018-10-29
The prognosis and treatment of hemangioendothelioma have not been well established. Hemangioma and hemangioendothelioma are moderately radiosensitive tumors. Hemangiomas involving the skeletal system have been treated effectively with local radiotherapy for many decades. Local radiotherapy is also u
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br mtDNA mutation in human cancers Several
2018-10-29
mtDNA mutation in human cancers Several authors have evaluated not only the quantitative change in mtDNA copy number, but also the qualitative mtDNA D-loop mutations in human cancers. D-loop mutations, including the D310 region, have been reported in prostate cancer, head and neck cancer, lung ca
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Epidemiological studies have documented many benefits
2018-10-29
Epidemiological studies have documented many benefits for cardiovascular health from drinking black tea. Black tea consumption lowered plasma uric crf hormone cost and C-reactive protein (CRP) levels in both man and women [41] (Table 4) and it also reduced serum glucose, triglyceride, LDL/HDL plasm
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Human iPSC lines are usually produced from fibroblasts isola
2018-10-29
Human iPSC lines are usually produced from fibroblasts isolated from skin biopsies, a traumatic invasive procedure demanding local anesthesia and medical follow-up. Hair follicle (HF) plucking, however, is simple, painless and a non-invasive alternative procedure. In the genuine study demonstrating
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Demonstrated here for the first time MKLP
2018-10-29
Demonstrated here for the first time, MKLP was observed in a hESC model system. Small MKLP particles are observed between mitotic spindles, large MKLP+ particles are observed aggregating in the lumen of neuroepithelial rosettes, and MKLP was not observed in the nucleus of hESC derived neural precurs
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Another recent initiative is ISSCR Connect an online
2018-10-29
Another recent initiative is ISSCR Connect, an online educational portal. The goal of ISSCR Connect is two-fold: first, to enhance the experience of those attending the ISSCR meeting, and second, to provide members with additional educational opportunities on a year-round basis and expand their acce
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Central to this method is the activation of canonical
2018-10-29
Central to this method is the activation of canonical WNT signaling by the GSK3β inhibitor CHIR. Expression profiling of hPSCs over the course of guided differentiation showed progression through defined developmental milestones leading to myogenesis. This transition was initiated by a strong induct
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Acknowledgments We thank Elisa Ronconi
2018-10-26
Acknowledgments We thank Elisa Ronconi for her assistance in preparing Fig. 1. We thank P Romagnani and G Remuzzi for their comment () on our paper (). The goal of our paper was to obtain a cell population enriched with adult renal stem isradipine exploiting the self-renewal characteristic, thr
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Another important advantage of this technical report is
2018-10-26
Another important advantage of this technical report is the successful application of dCas9 activators for validation of PAX7 knock-in reporter order AZD-9291 (Cheng et al., 2013). By design and assembly of site-specific dCas9 activators for PAX7 in human iPS cells, these activators have been screen
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Collectively we have evaluated the impact of a MODY causing
2018-10-26
Collectively, we have evaluated the impact of a MODY5-causing point mutation (S148L) in the HNF1B gene on human pancreas development using a unique human stem cell model. We report molecular phenotypes (up- and down-regulation of pancreatic genes) when HNF1B is increasingly expressed from days 7 to
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Multiple factors through binding to GPCRs orchestrate
2018-10-26
Multiple factors, through binding to GPCRs, orchestrate the regulation of cAMP levels in a cell- and context-dependent manner, an effect that is most likely to be preserved during embryonic hematopoietic emergence and development (Diaz et al., 2015; Goessling et al., 2011; Hoggatt et al., 2009; Jing
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Tau helps assemble and stabilize microtubules In the CNS
2018-10-26
Tau helps assemble and stabilize microtubules. In the CNS, several isoforms of tau are produced from a single gene by alternative splicing (Goedert et al., 1989). More than 40 pathogenic MAPT mutations have been described in more than 100 families with FTD (Cruts et al., 2012; Alzheimer Disease & Fr
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