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br Research limitations and strengths br Implication of the
2018-11-12
Research limitations and strengths Implication of the study Conclusions Introduction: current world toilet habits Home design is a unique, collaborative yet challenging exercise for architects, designers and builders because it adenosine receptor involves design issues relating to perso
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It is now well established that hypoxia between and oxygen
2018-11-12
It is now well established that hypoxia between 1% and 5% oxygen facilitates induction and maintenance of immature cellular phenotypes ranging from mesenchymal stem order dihydroergotamine to satellite cells and embryonic stem cells (Prasad et al., 2009; Yang et al., 2012), and it appears that this
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Modulation of GASZ by ectopic overexpression or by RNA
2018-11-12
Modulation of GASZ by ectopic overexpression or by RNA interference in ESCs affected several key germ cell markers, such as Oct4, Dazl, Mvh, Miwi, and Mili, which may in turn contribute to the altered PGC or EGC derivation from differentiated EBs. Since GASZ is localized in the intermitochondria cem
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In pluripotent cells phosphorylation has
2018-11-12
In pluripotent cells, phosphorylation has a central role in directing cell identity by relaying growth-factor signaling through key pathways (i.e., fibroblast growth factor [FGF] and transforming growth factor β [TGF-β]) (Chen et al., 2011; Singh et al., 2012a; Vallier et al., 2005; Yu et al., 2011)
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Recently efforts have been made to
2018-11-12
Recently, efforts have been made to identify differently expressed proteins during the osteogenic differentiation of hBMSCs (Alves et al., 2010; Foster et al., 2005; Kim et al., 2008, 2010; Ong and Mann, 2006; Zhang et al., 2007). These types of studies will not only increase our understanding of th
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PX-478 2HCl The following are the supplementary data related
2018-11-12
The following are the supplementary data related to this article. Introduction Materials and methods Results Discussion Within the human body, three mechanisms of blood vessel formation can be distinguished, namely vasculogenesis, arteriogenesis and angiogenesis. In particular angiogene
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For some genes the difference in transgene
2018-11-12
For some genes, the difference in transgene expression in BM/blood and other target organs can be both quantitative and qualitative. For example, the activities of introduced purchase win 55 212-2 α-glucosidase, which is deficient in a lysosomal glycogen storage disorder, Pompe disease, were differe
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Introduction Previous studies describing functional recovery
2018-11-09
Introduction Previous studies describing functional recovery following transplantation of neural stem/progenitor pannexin-1 inhibitor (NS/PCs) in spinal cord injury (SCI) models demonstrated the therapeutic promise of this approach (Cummings et al., 2005; Iwanami et al., 2005). A number of putativ
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Introduction The pluripotency promoting role
2018-11-09
Introduction The pluripotency-promoting role of the reprogramming factors OCT4, SOX2, KLF4, and MYC (OSKM) is widely appreciated. However, these reprogramming factors also promote expression of non-pluripotency genes. For example, OCT4 (Pou5f1) directly promotes expression of genes important for mo
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Retinoblastoma proteins complex with E F and DP
2018-11-09
Retinoblastoma proteins complex with E2F and DP family transcriptional repressor proteins (Bertoli et al., 2013) to both activate and repress gene expression associated with regulation of cell-cycle repression and differentiation. Rbf-E2F1-DP complexes regulate transient gene expression necessary fo
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Upon exposure to an oxidant USP inhibits ROS dependent
2018-11-09
Upon exposure to an oxidant, USP10 inhibits ROS-dependent apoptosis by reducing ROS production (Takahashi et al., 2013b). Since aberrant ROS production has been shown to be a critical apoptosis inducer of HSCs under basal and stress conditions (Naka et al., 2008), it was initially assumed that USP10
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TSC haploinsufficient astrocytes presented a high proliferat
2018-11-09
TSC haploinsufficient astrocytes presented a high proliferation rate and an increased saturation density when compared with WT astrocytes. Similarly, the conditional disruption of TSC1 in astrocytes using a human GFAP-Cre system was shown to produce mice that presented with astrocytosis (Han and Sah
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For phonetic learning this raises the question of whether
2018-11-09
For phonetic learning, this raises the question of whether infants’ perceptual attunement is likewise context-dependent, taking into account language-specific phonological processes and the contexts in which they apply. Nine-month-old infants are sensitive to phonological context: they have acquired
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The following are the supplementary
2018-11-09
The following are the supplementary data related to this article. Potential conflicts of interest Author contributions Acknowledgements This work was supported by the Defense Advanced Research Projects Agency (DARPA) grant N66001-11-1-4180 and the Wyss Institute for Biologically Inspired E
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HEV may also contribute to various extrahepatic manifestatio
2018-11-09
HEV may also contribute to various extrahepatic manifestations, including pancreatitis, hematological disorders (thrombocytopenia and anemia), kidney disorders and neurological complications (Guillain-Barré syndrome and meningoencephalitis) (Singh and Gangappa, 2007; Thapa et al., 2009; Wedemeyer et
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