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Collagen X is a homotrimeric
2019-07-18
Collagen X is a homotrimeric molecule of three α1(X) chains (Mr 59 kDa) comprising a 45 kDa triple-helical domain flanked by an N-terminal (NC2) and a larger C-terminal (NC1) non-collagenous domains (Shen, 2005). In the hypertrophic ECM, collagen X most likely forms an extended hexagonal network, as
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In astrocytes mitogen activated protein kinases MAPKs are ac
2019-07-18
In astrocytes, mitogen-activated protein kinases (MAPKs) are activated after OGD-induced ischemic injury (Yung and Tolkovsky, 2003, Niu et al., 2009) and they regulate induction of AQP expression (Arima et al., 2003, McCoy and Sontheimer, 2010). It is well known that MAPKs, including extracellular s
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A genomic DNA sequence was
2019-07-18
A genomic DNA sequence was retrieved (Scaffold_30) from the fugu genomic database ( v3.0), which encodes the homolog of CXCL8 of many other vertebrates and specific primers CXCL8F1 and CXCL8R1 () were designed for 3′-RACE and 5′-RACE PCR, respectively. First-strand thymus cDNA was used as template.
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br Results and discussion Compounds were tested for their
2019-07-18
Results and discussion Compounds were tested for their binding affinity to human CRTH2 in a radioligand binding assay (3H-PGD2) using CHO cells stably transfected with human CRTH2. In addition, these compounds were assessed for their functional activity in PGD2 driven Ca2+ flux in KB8 cells expre
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Application of the CPH model
2019-07-18
Application of the CPH model relies on the assumption that the hazard ratio of two observations is constant over time [2]. This enables us to infer the rate of risk of the treatment. For example, in the study of patients with pulmonary arterial hypertension (PAH) [5], the hazard ratio of a group of
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Pemetrexed On close inspection the pattern shows
2019-07-18
On close inspection, the pattern shows large areas of very low point intensity where hardly any trees can be found. Anecdotal knowledge reveals that these regions are covered by a swamp, where the tree species is known to be very unlikely to grow, independent of local soil covariates and topography.
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Since the interaction between the E and E
2019-07-18
Since the interaction between the E2 and E3 is weak and transient, it has been difficult to identify novel interactions between specific E2/E3 complexes [59], [64]. Here we used a modified bait consisting of the Mulan RING domain fused to one of the four E2s isolated in our screen and expressed in y
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GLP signaling mediates important renal functions as suggeste
2019-07-18
GLP-1 signaling mediates important renal functions [101], as suggested by the expression of both DPP-4 and GLP-1R in the kidney of several species, including humans [102]. However, controversial data exists on the specific expression pattern of these proteins, based on the specificity and sensitivit
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Our data also showed that D dopamine receptor was down
2019-07-18
Our data also showed that D2 dopamine receptor was down-regulated in the hippocampus, NAc and striatum of F1-MEP animals, which was only significant in the hippocampus. Both agonists and antagonists of D2 dopamine receptor are able to decrease heroin self-administration (Hemby et al., 1996; Rowlett
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Dipeptidyl peptidase inhibitors DPP is or gliptins stimulate
2019-07-18
Dipeptidyl peptidase-4 inhibitors (DPP-4is or gliptins) stimulate both post-meal insulin secretion and inhibit β-Sitosterol solubility secretion in a glucose-dependent manner, rendering the risk of hypoglycaemia minimal [10]. They are weight-neutral or may even induce slight weight loss. Their good
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The human serotonin hydroxytryptamine HT receptor family con
2019-07-18
The human serotonin (5-hydroxytryptamine; 5-HT) receptor family consists of 14 receptor subtypes to date, which are primarily G protein-coupled receptors (GPCRs) with 5-HT3 being the sole ligand-gated ion channel (Alexander et al., 2017). These receptors are widely distributed in the central and per
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br Materials and methods br
2019-07-18
Materials and methods Results Discussion A reporter of FGF signaling activity has long been sought to facilitate the quantitative real-time analysis of pathway activity at single-cell resolution. Here we report the generation of a Spry4 reporter allele in ESCs and mice that recapitulates kn
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Therefore evaluation of base substances of alkali activated
2019-07-18
Therefore, evaluation of Schaftoside is substances of alkali-activated paste and alkali solution dosages have a remarkable impact on output products. Few research can be found in literature to assess GGBFS as a base materials of AAC. Even though less studies exists for serving RHA as base substance
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In a study performed simultaneously by another group EWS
2019-07-18
In a study performed simultaneously by another group, EWS-FLI-1 introduction into unsorted murine bone marrow-derived AG 1879 resulted in tumors with various phenotypes including one that is consistent with that of Ewing sarcoma [68]. The tumors expressed markers associated with Ewing sarcoma and d
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All tested antibodies exhibited positive immunoreactivity in
2019-07-17
All tested SNX-2112 exhibited positive immunoreactivity in NSCLC tumors, with N’-epitope being the less expressed (both as overall positivity and number of positive cases, or intensity combined with number of positive cells, as provided by H-Score. This result is in accordance with previous studies
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