• Human fibroblasts were reprogrammed from an individual

  2018-10-24

  

  Human fibroblasts were reprogrammed from an individual into nociceptor neurons without creation of iPSCs and the neurons exhibited sensitization to the chemotherapeutic drug oxaliplatin, modeling the inherent mechanisms underlying painful CIPN (Wainger et al., 2015); however, the advantage to creati

• Sca has for a number of years been

  2018-10-24

  

  Sca-1 has for a number of years been used as a positive marker to isolate stem cells or progenitor cells from a number of tissues (Spangrude et al., 1988; Klimmeck et al., 2014; Holmes and Stanford, 2007). Inclusion of order tropisetron against Sca-1 in the antibody panels is now more or less standa

• In our previous studies we successfully synthesized poly hyd

  2018-10-24

  

  In our previous studies, we successfully synthesized poly(hydroxyethyl methacrylate) (pHEMA) derived-polymers differing in the amount of 2-methacryloyloxyethyltrimethyl ammonium chloride (METAC) (Rosso et al., 2003; De Rosa et al., 2004). We demonstrated that positively charged moieties on the polym

• Since BMP secretion in the bone marrow microenvironment

  2018-10-24

  

  Since BMP4 secretion in the bone marrow microenvironment is essential for hematopoietic recovery (Goldman et al., 2009), an inhibitor of BMP4 signaling cannot be used to prevent irradiation-induced BMP4-mediated marrow adipogenesis. Inhibition of PPAR-γ has already been shown to prevent post-irradia

• protein phosphatase Direct cell reprogramming technology is

  2018-10-24

  

  Direct cell-reprogramming technology is based on the dominant action of cell-lineage transcription factors (TFs) in converting adult somatic cells into different cell types (Graf and Enver, 2009). This technique represents a promising avenue in the field of regenerative medicine, with the potential

• Transplantation of iPSC NSCs within the neonatal brain yield

  2018-10-24

  

  Transplantation of iPSC-NSCs within the neonatal jasplakinolide yielded stable engraftment across the neuroaxis for at least 4 months, but only within and adjacent to white matter tracts. Although the precise mechanisms are unclear, NSCs from various sources display a tropism for white matter in bo

• br Acknowledgements This work was supported by the

  2018-10-24

  

  Acknowledgements This work was supported by the IRET Foundation (2015-2016), Ozzano Emilia, Italy (no-profit organization), in the frame of the “Step-by-step” POR-FESR 2016-2020 Emilia Romagna Region project. Introduction Resident neural stem cells (NSCs) persist in the adult mammalian centr

• Existing treatments for myelomeningocele repair consist of p

  2018-10-24

  

  Existing treatments for myelomeningocele repair consist of pre- or post-natal surgical closure of the defect. Prenatal intervention has been shown to be more effective than postnatal surgery because it can prevent or ameliorate sequels (Adzick et al., 2011; Adzick et al., 1998; Meuli et al., 1997; M

• In addition to studying drug effects on AP and

  2018-10-24

  

  In addition to studying drug effects on AP and calcium handling, we also showed the potential of using genetic reporters for studying inherited arrhythmogenic disorders. To this end, we utilized a previously established LQTS2 patient-specific line (Itzhaki et al., 2011a) and also generated a new hiP

• Importantly because none of these markers are

  2018-10-24

  

  Importantly, because none of these markers are specific for trophoblast or trophoblast populations in general, they must be used in combination. For example, SWAN-71 and HTR8/SVneo, two widely used “trophoblast” cell lines, are hypermethylated at the ELF5 promoter, HTR8/SVneo does not express C19MC

• br Results br Discussion We have successfully established a

  2018-10-24

  

  Results Discussion We have successfully established a human stem cell model to study the molecular mechanisms underlying MODY5. Our experimental design, which includes a non-family control hiPSC line and three independent hiPSC lines from each of the three subjects in a MODY5 family, is a well

• cyclooxygenase pathway Previous reports have described ESC b

  2018-10-24

  

  Previous reports have described ESC-based differentiation in collagen gels to study the developmental events of vasculogenesis and angiogenesis (Feraud et al., 2001; Hermant et al., 2007). However, these were not optimized for the assessment of more fundamental aspects of vessel induction, patternin

• We provide evidence that RUNX has a role in

  2018-10-24

  

  We provide evidence that RUNX1 has a role in early mesendodermal differentiation of hESCs through regulation of cell migration and adhesion, as indicated by impairment of these processes upon RUNX1 depletion. These findings are consistent with the emerging role of RUNX1 in controlling cell motility

• Microcephaly is a neurodevelopmental disorder where the head

  2018-10-24

  

  Microcephaly is a neurodevelopmental disorder where the head is smaller than the typical size during fetal development and at birth, with the circumference less than 2 SDs below the mean (Centers for Disease Control and Prevention, 2016b). Babies with microcephaly can have a wide array of problems s

• Stem cell research and the

  2018-10-24

  

  Stem cell research and the ISSCR have undergone enormous growth over the past 15 years, as evidenced by the strength of basic research programs, industry, and clinical trials that are pioneering the field of regenerative medicine. As the ISSCR celebrates its milestone 15th anniversary, we ask for yo

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