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Nicotinic Acid Results of the present study demonstrate that
2021-03-26
Results of the present study demonstrate that 25-OHC treatment of THP-1 monocytes induced vimentin intermediate filament reorganization to more cortical structures and a polarized phenotype (Fig. 5). Vimentin is the major intermediate filament protein present in leukocytes and plays an important rol
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The differences between ground and transition state properti
2021-03-26
The differences between ground and transition state properties are exemplified by a comparison of our human–yeast results with those of a structural study of possible differences in ubiquitin-Uba-1 binding in yeast (known structure) with human (simulated in [12]). Their discussion focuses on Ubiquit
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Leupeptin In many studies spatial and temporal
2021-03-26
In many studies, spatial and temporal expression and subcellular localizations of the DNMTs are examined in greater detail. These studies are evaluated and discussed in the remaining part of the article. DNMT1 protein expression was characterized in the genital ridge of the primitive mouse gonad at
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In this context we initiated a program to develop
2021-03-26
In this context, we initiated a program to develop new antiviral chemotypes towards a host factor implicated in Rhapontigenin replication: the host (human) dihydrofolate reductase (DHFR) [21]. We recently identified this enzyme as the molecular target of 1-aryl-4,6-diamino-1,2-dihydrotriazines, str
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br Experimental br Results and discussion br Conclusions In
2021-03-26
Experimental Results and discussion Conclusions In this work we presented the direct electrochemical behaviour of the Mo containing formate dehydrogenase, purified from D. desulfuricans, where the Mo centre redox features were observed. The results allowed to calculate the reduction potenti
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Dexamethasone DEX a potent synthetic glucocorticoid
2021-03-26
Dexamethasone (DEX), a potent synthetic glucocorticoid drug, is effective for treatment of a range of inflammatory and autoimmune conditions as well as the reduction of side effects associated with chemotherapy. On the Czech Republic pharmaceutical market, DEX is incorporated into eighteen drugs use
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Testosterone is inactivated through hydroxylation and conjug
2021-03-26
Testosterone is inactivated through hydroxylation and conjugation pathways [3], [4]. 6β-Hydroxylation is the main pathway among testosterone hydroxylation processes in the liver microsome. Testosterone 6β-hydroxylation is mainly catalyzed by cytochrome P450 3A (CYP3A) [5], [6], which is expressed in
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After the policy of the
2021-03-26
After 1915, the policy of the (current) British Commonwealth countries (including Britain, Canada, Australia, India, New Zealand and South Africa) regarding the dead, was to ensure that as far as possible, whether identified or not, all recovered bodies would be given individual graves, with standar
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The proposed FDIR technique is
2021-03-26
The proposed FDIR technique is presented in the following format: Section 2 contains a survey of typical orbits of interest with regard to the A 205804 australia environment found in them, which is contrasted with a LEO orbit. Additionally, how the requirements for the satellite system can be estim
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In this study CK C prepared from BL DE
2021-03-26
In this study, CK1δ(ΔC) prepared from BL21(DE3)pλPP had the highest kinase activity among the three isoforms tested when using casein as a substrate. Therefore, CK1δ(ΔC) from BL21(DE3)pλPP has the potential to be a “phosphorylating reagent” that may be widely used in experiments of phosphorylation a
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br Methods br Results Main characteristics of study
2021-03-25
Methods Results Main characteristics of study population are presented in Table 1. AD cases had higher co-morbidity score and lower socioeconomic position than controls. Women with AD had undergone any surgery (unilateral/bilateral oophorectomy, hysterectomy, hysterectomy with bilateral oophor
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L-Carnitine inner salt br Introduction Cell transplantation
2021-03-25
Introduction Cell transplantation therapies using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC)-derived retinal tissue (ESC/iPSC retina) or L-Carnitine inner salt have emerged as therapeutic options for retinal degeneration following recent breakthroughs. A number of groups
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Four m thick sections of formalin fixed
2021-03-25
Four-μm thick sections of formalin-fixed paraffin-embedded tissue samples from uterine cervical cancers were cut with a microtome and dried overnight at 37 °C on a silanized-slide (Dako, Carpentaria, CA, USA). The protocol of the universal Dako Labeled Streptavidin–Biotin kit (Dako) was followed for
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devd Several recent reviews have appeared covering
2021-03-25
Several recent reviews have appeared covering different aspects of the sPLA2 family of enzymes, including sPLA2-V, and the interested reader is kindly directed to these for specific details [34,[135], [136], [137]]. It is important to remark here, however, that recent studies on sPLA2-V suggest that
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Imeglimin hydrochloride br Conflict of interest br Acknowled
2021-03-25
Conflict of interest Acknowledgements We wish to thank Arantza Pérez (University of the Basque Country) for her technical contribution to this study. This work was supported by grants from the Jesús Gangoiti-Barrera Foundation, Gobierno Vasco (GIC07/84), MEC () and SAIOTEK (SA-2008/00046).
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