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Recently several Pt IV complexes as prodrugs
2021-04-16
Recently, several Pt(IV) complexes as prodrugs have been designed and studied to enhance anti-tumor efficacy of traditional Pt(II) drugs, improving their cellular uptake and blood-circulation time [26], [27], [28], [29]. Compared with their Pt(II) counterparts, six-coordinated Pt(IV) complexes with
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The mechanisms by which coregulators control the actions of
2021-04-16
The mechanisms by which coregulators control the actions of estrogen receptors are still a topic of ongoing research. From studies in cancer cells, we have learned that a large group of coregulators have specific structural motifs that than affect their contact with ER ligand-binding domains (Heery,
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Although the presence of calcium
2021-04-16
Although the presence of calcium in RHA-P active site is confirmed by the homology modeling, some additional observations can be made following the metal depletion and reconstitution experiments performed on RHA-Phis. EDTA-treated RHA-Phis recovers its activity in the presence of divalent cations su
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EP receptors belong to the family of G
2021-04-16
EP1–4 receptors belong to the family of G protein-coupled receptor (GPCR). Trafficking events such as externalization, internalization, recycling and degradation dynamically regulate GPCR cell surface density. A fast-rate of internalization and degradation reduces GPCR surface density to desensitize
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In principle in vitro techniques for assessing
2021-04-16
In principle, in vitro techniques for assessing enzyme induction might include the use of cultured hepatocytes, precision-cut liver slices, immortalized enfuvirtide lines (such as those derived from hepatomas) and reporter gene constructs (where appropriate cells are transfected with recombinant DNA
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br DUBs in regulation of critical steps in tumor
2021-04-16
DUBs in regulation of critical steps in tumor metastasis Tumor metastasis comprises a complicated series of biological processes in terms of the invasion-metastasis cascade that requires cancer AH 7614 to (1) migrate and invade from the origin sites through the extracellular matrix (ECM) to the s
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Long stretches of ssDNA have also been
2021-04-16
Long stretches of ssDNA have also been observed in rad53-1 mutant Sephin 1 under replication stress using EM images (Sogo et al., 2002). Deletion of EXO1, a 5′-to-3′ exonuclease, can suppress the generation of ssDNA detected in rad53-1 mutant cells (Cotta-Ramusino et al., 2005). It was thus proposed
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Even though Et modification of DNA delayed
2021-04-16
Even though Et743 modification of DNA delayed the progress of the translocating enzyme significantly, it did not trap RecBCD on DNA, nor did it alter the activity of the enzyme significantly. Under catalytic conditions, no loss of enzyme activity was observed (Table 2), nor were stable unwinding int
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For the SAR optimization of the right
2021-04-15
For the SAR optimization of the right hand side, it was decided to explore the inclusion of the key carboxylic 2-Amino-ATP sale moiety present in the original DGAT-1 inhibitors from . Analogs were constructed by the synthetic routes outlined in , . In , the methylene-oxy linker was introduced by con
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br Preparation of Recombinant Proteins br Activity Assays Th
2021-04-15
Preparation of Recombinant Proteins Activity Assays The following solvents are used in the procedures described in this section: Data Analysis Aryl radical rearrangements typically result in a large number of products being generated by Bmp7. Approaches combining mass spectrometry and NMR
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br CXCR CXCR is a homeostatic chemokine
2021-04-15
CXCR5 CXCR5 is a homeostatic chemokine receptor for lymphocytes and plays a critical role in the development of lymphoid organs as well as regulating the interaction between antigen presenting cells and lymphocytes (Cannons et al., 2012). It is one of the major chemokine receptors dictating norma
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Acknowledgments br Introduction Various researches have been
2021-04-15
Acknowledgments Introduction Various researches have been made in the field of the treatment of cancer and inflammatory diseases. Different mechanisms are involved in the progression of cellular damage that gives an idea about new drug targets. There are always some efforts to improve efficacy,
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Pattern separation is a process that takes place
2021-04-15
Pattern separation is a process that takes place in the hippocampus and more specifically in the dentate gyrus (DG) and Cornu Ammonis region 3 (CA3) (Morris, Churchwell, Kesner, & Gilbert, 2012). The main source of input in the hippocampus is derived from the enthorinal cortex (EC) that mainly proje
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The observed increase in Bdnf mRNA occurred h after treatmen
2021-04-15
The observed increase in Bdnf1 mRNA occurred 1 h after treatment indicates participation of BDNF in early plasticity and subsequently mnemonic processes. Most of the evidence regarding the importance of BDNF for memory formation derived from electrophysiological studies that utilized the molecular c
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The proposed FDIR technique is
2021-04-15
The proposed FDIR technique is presented in the following format: Section 2 contains a survey of typical orbits of interest with regard to the 10537 environment found in them, which is contrasted with a LEO orbit. Additionally, how the requirements for the satellite system can be estimated is prese
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