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EBI is known to play a
2021-08-16
EBI2 is known to play a critical role in the induction of antibody responses in secondary lymphoid tissues.13, 14 However, little is known about the expression and function of EBI2 in human peripheral tissues. To our knowledge, this is the first report of increased EBI2 levels in peripheral tissues
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br Competing interests br Acknowledgements br Introduction D
2021-08-16
Competing interests Acknowledgements Introduction Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) in biomembranes to produce phosphatidic estrone (PA) [1], [2], [3], [4], [5], [6]. To date, ten mammalian DGK isozymes (α, β, γ, δ, ε, ζ, η, θ, ι and κ) have been identified. Th
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A novel series of DHODH inhibitors was developed by us
2021-08-16
A novel series of DHODH inhibitors was developed by us based on a lead that was discovered during a docking procedure and medicinal chemistry exploration. The activity of the initial lead was improved by a QSAR method and yielded low nanomolar inhibitors. Introduction The most common metabolic h
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Consistent with previous simulations on
2021-08-16
Consistent with previous simulations on the DFG-Asp-out/-in interconversion of Abl kinase, we only observe the DFG flip with protonated Asp747 (Shan et al., 2009). We showed previously that the pKa for the DFG-Asp in Abl is elevated at 6.5. Further “constant pH” simulations whereby protonation event
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10-Hydroxycamptothecin br Acknowledgements The study was sup
2021-08-14
Acknowledgements The study was supported by grant no. 501-003-11043 from the Institute of Psychiatry and Neurology in Warsaw. The authors thank Mrs. Ala Biegaj for the excellent technical assistance. Introduction In an effort to identify hIFN receptor molecules encoded by a gene(s) within hum
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The use of AACSB accreditation as an indicator
2021-08-14
The use of AACSB accreditation as an indicator of expected performance on the CPA exam has been examined by prior studies (e.g. Barilla et al., 2008, Boone et al., 2006, Grant et al., 2002, Howell and Heshizer, 2006, Lindsay and Campbell, 2003, Marts et al., 1998). While these studies are based on d
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RQ What are the different
2021-08-14
RQ2: What are the different factors that influence the decision to choose among different component origins? In total eleven factors grouped into three high-level themes that influence the decision to choose a component origin were identified. The project metrics factors are: time, cost, effort and
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Located on the fore tarsals of
2021-08-14
Located on the fore-tarsals of the front pair of legs, the Haller’s organ is presumed central to tick chemosensation. Recent genomic, transcriptomic and proteomic investigations have identified several families of transmembrane proteins in the forelegs of ticks that are likely involved in olfactory
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We observed the IVM potentiation of currents
2021-08-14
We observed the IVM potentiation of currents induced by the EC5 of Glu or GABA and the IVM inhibition of currents induced by the EC90 of Glu or GABA in wild-type GluCls and GABACls. The EC50 of IVM for the potentiation in GluCls was 3.5-fold smaller than that in GABACls (Fig. 4, Fig. 8B, Table 2), a
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Pirarubicin Exogenous administration of POCs could theoretic
2021-08-14
Exogenous administration of POCs could theoretically inhibit breastfeeding [69]; however, the evidence in this review does not generally support a negative impact on breastfeeding outcomes. Studies examining the Pirarubicin of POCs among postpartum women overall demonstrated no adverse effects on me
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In rodent models the loss of
2021-08-14
In rodent models, the loss of estrogens through ovariectomy has been shown to promote the development of intracranial aneurysms. Conversely, the administration of an mek inhibitors receptor beta agonist restores its protective effect, but is abolished with the introduction of a nitric oxide synthas
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Abbas et al studied the
2021-08-14
Abbas et al. studied the mitigation of ASR in their corresponding study by incorporating RHA [1]. These researchers used Ordinary Portland Cement (OPC), four different percentages (i.e., 10%, 20%, 30% and 40% by weight of OPC) of RHA and reactive aggregate (sand from Dolomite-limestone rock) in thei
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br Acknowledgements br Introduction Ischemic retinopathy
2021-08-14
Acknowledgements Introduction Ischemic retinopathy is common to the major causes of blindness, including proliferative diabetic retinopathy, venous occlusion, and retinopathy of prematurity. The hypoxia that follows retinal capillary obliteration drives deregulated growth of new blood vessels
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ERR is present early in
2021-08-14
ERRβ is present early in the developing placenta in a subset of glycine receptors in extra-embryonic ectoderm destined to make up the chorion.19, 20 ERRβ is likely essential for reproduction. ERRβ expression is essential for the maintenance of pluripotency and self-renewal potential in mouse embryo
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br Non cyclic nucleotide EPAC regulators Despite the success
2021-08-14
Non-cyclic nucleotide EPAC regulators Despite the success of 007 as a tool molecule, few studies to date have led to the identification of further EPAC-selective agonists. The most studied and controversial group of small-molecule EPAC regulators are the sulfonylurea (SU) family. SUs (Table 1) su
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