• Despite the importance of intratumor phenotypic

  2022-01-07

  

  Despite the importance of intratumor phenotypic heterogeneity for tumor progression and therapy resistance (Marusyk et al., 2012, Marusyk and Polyak, 2010), our understanding of regulators of this process and our ability to modulate them are very limited. Recent advances in genomic sequencing and si

• br Introduction Regulation of transcription

  2022-01-07

  

  Introduction Regulation of transcription is a critical event of the embryonic development and epigenetic mechanisms such as histone modifications and DNA methylation appear important in mediating temporal changes, and differences among cells/tissues, of temporary stabilized transcriptomes (Mas et

• br Conclusion br Acknowledgement br Introduction Biogenic am

  2022-01-07

  

  Conclusion Acknowledgement Introduction Biogenic amine histamine is synthesized from L-histidine by histidine decarboxylase (HDC). Histamine is involved in a wide variety of pathological and physiological processes including allergic reactions, inflammation, immune responses, gastric secret

• br Mechanism of HH pathway

  2022-01-07

  

  Mechanism of HH pathway activation in NSCLC Despite the role of the HH pathway in basal cell carcinoma and medulloblastoma, it has been postulated that epithelial tumors do not demonstrate cell autonomous HH ligand activity. The main evidence comes from the study by Yauch et al showing no correla

• For further understanding of the

  2022-01-07

  

  For further understanding of the interaction between these inhibitors and proteins (BRafV600E and HDAC1) for guiding the SAR, compound 10e, the most potent compound of this series, was chosen as a representative for docking into the BRafV600E (PDB code: 1UWJ) and HDAC1 (PDB code: 1C3R), revealing ex

• In our previous studies examining erectile responses in

  2022-01-07

  

  In our previous studies examining erectile responses in sGCα1−/− mice, we found that the sGCα1 subunit was required to obtain proper erectile responses to substances generally known to exert their actions by sGC.17, 18 Based on our previous observation of residual relaxing responsiveness to exogenou

• br Materials and methods br Results As

  2022-01-07

  

  Materials and methods Results As expected, due to matching by age, the mean ages were similar for the two groups of children when stratified by ASD status; children with an ASD had a mean age of 67.0 months, while the mean age for children in the TD control group was 68.0 months. Nearly all of

• br GSNOR activity and functions The identification of the

  2022-01-07

  

  GSNOR activity and functions The identification of the enzyme responsible for GSNO decomposition dates back to 1998, when Jensen and colleagues described an NAD(P)H-dependent GSNO catabolizing activity in cytosolic fractions obtained from rat liver [16]. Upon purification, they identified this en

• knowing it br Some Gardos channel perplexities While much is

  2022-01-06

  

  Some Gardos channel perplexities While much is known about the Gardos channel (inside Ca2+-activated K+ channel) and it's characteristics in human red blood knowing it (e.g. [18,19]), there are a number of intriguing and unexplained phenomena that are in much need of study. One is that activatio

• Amongst oxidants that we have studied PMS is unique

  2022-01-06

  

  Amongst oxidants that we have studied, PMS is unique in having a greater effect in deoxygenated cells. The resulting phenotype shows some similarities with the increased cation permeability shown by deoxygenated sickle zingerone [27]. It is interesting to consider why PMS has this effect. PMS funct

• Our own search towards aryl imidazole

  2022-01-06

  

  Our own search towards aryl-imidazole derived GSMs led to the discovery of the benzimidazole derivative (). It is one of the most potent GSMs to date, suffering however from sub-optimal drug-like properties. More recently, we have described the design and synthesis of bicyclic triazolo-derivatives,

• It should be noted that the applied steered

  2022-01-06

  

  It should be noted that the applied steered unfolding of the i-motif and G-quadruplex satisfies the conditions of Jarzynski inequality for computations of the free energy change. [41] However, in order to reproduce the free energy with an adequate quality a number of nonequilibrium unfolding transit

• Corresponding to the different insulinotropic signaling the

  2022-01-06

  

  Corresponding to the different insulinotropic signaling, the competitive radioligand-binding studies demonstrated at least 3 distinct BX-912 on GPR40: orthosteric binding site for endogenous ligands, allosteric binding site for partial agonists and another allosteric binding site for full agonists

• For our test subjects we used

  2022-01-06

  

  For our test subjects, we used established high fat diet–induced obese (eDIO) male mices T2DM models. The establishment of eDIO mice was accomplished with a 60% high fat diet ad libitum over a 14 week period (initiated at 6 weeks of age). Compared with regularly-dieted mice, the eDIO ones weigh sign

• We characterized the enzyme corresponding to N FPP was the

  2022-01-06

  

  We characterized the enzyme corresponding to N1. FPP was the most effective substrate as allylic diphosphate, and the activities with GPP and DMAPP were 50% and 11% that with FPP, respectively. The analysis of the prenols resulting from the treatment of prenyl diphosphates with POM 1 phosphatase ()

15417 records 471/1028 page Previous Next First page 上5页 471472473474475 下5页 Last page