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To confirm a role of OCT in corticosterone induced
2024-07-15
To confirm a role of OCT3 in corticosterone-induced potentiation of cocaine-primed reinstatement, we examined the interaction of corticosterone and cocaine in the reinstatement of cocaine conditioned place preference (CPP) in wild type mice, and transgenic OCT3-deficient mice. These mice express a t
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To validate the identified phosphorylation sites in
2024-07-15
To validate the identified phosphorylation sites in the mouse heart, we analyzed HEK 293T lactone transfected with Adrb1 based on the hypothesis that protein residues phosphorylated both in vivo and in vitro are more likely to be physiologically relevant. All of the phosphorylation sites identified
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br Materials and methods br Results br Discussion More exper
2024-07-15
Materials and methods Results Discussion More experiments were performed in order to explain the mechanism that is involved in glut 1 death both PC3 and Hep G2 cells using compound 5. Results showed that this compound inhibits cell viability inducing apoptosis in a concentration-dependent
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br Materials and methods br Results br Discussion
2024-07-15
Materials and methods Results Discussion This study demonstrates that treatment with a selective adenosine kinase inhibitor ABT-702, thereby enhancing extracellular adenosine, can provide partial protection from age-related hearing loss in C57BL/6J mice. Chronic treatment with ABT-702, comm
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In an insightful essay Heryanto writes that language
2024-07-15
In an insightful essay, Heryanto (1990, 40) writes that language is “a phenomenon expressing the particular history of a society” that did not exist in many parts of the world. “Language is not a universal category or cultural activity. Though it may sound odd, not all people have a language in the
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Given that there are substitutions between Anc and the human
2024-07-15
Given that there are 132 substitutions between βAnc and the human β subunit, we wondered whether βAnc could replace the human β subunit in hybrid AChRs formed from ancestral and human subunits. We first confirmed that the β subunit is required for expression of human AChRs in HEK293 AR-A014418 sale
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Eicosanoids are locally acting signaling lipids that are
2024-07-15
Eicosanoids are locally acting signaling lipids that are produced from C20 polyunsaturated fatty acids (PUFAs), including arachidonic Sweroside mg (AA, C20:4), eicosapentaenoic acid (C20:5) and eicosatrienoic acid (C20:3) (Dennis and Norris, 2015; Funk, 2001; Stables and Gilroy, 2011). According to
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Another significant group of reductase inhibitors is the ste
2024-07-15
Another significant group of 5α-reductase inhibitors is the steroidal 3-carboxylic Deoxycholic acid derivatives (relevant examples in Fig. 5), which were designed to mimic the putative enzyme-bound enolate intermediate. This was achieved by introducing sp2-hybridized centers at C3 and C4 and an ani
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535 2 Stroke also known as a cerebrovascular
2024-07-15
Stroke, also known as a cerebrovascular accident or 535 2 attack, is one of the leading causes of death and disability worldwide (Haley et al., 2017; Hankey, 2017; Lie et al., 2017). According to the data released by the World Health Organization (WHO), stroke occurs every 5 s worldwide (WHO, 2016)
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br Results and discussion br Conclusion In summary a series
2024-07-15
Results and discussion Conclusion In summary, a series of indazole-based derivatives were synthesized and SAR studies conducted, with view to the development of a novel Aurora kinases inhibitor. The carboxylic Manumycin A group extending from the C-3 position of the aniline and substituted gr
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br Conflicts of interest br Introduction
2024-07-15
Conflicts of interest Introduction Phosphatidic 8351 phosphatase (PAP) enzymes are responsible for catalyzing the reaction that dephosphorylates phosphatidic acid (PA), which in turn produces diacylglycerol (DAG) and a phosphate group during phospholipid regulation (Fig. 1A) [1]. Subsequently,
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The co crystal structure of
2024-07-15
The co-crystal structure of ()-blebbistatin ()- bound to myosin II (PDB: ) was used to scout for possible favorable interactions with the residues lining the binding pocket. Looking at A, we hypothesized that -oriented hydrophilic moieties (e.g. hydroxymethyl) on C of the blebbistatin scaffold migh
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Starting with commercially available or nitropyrazole carbox
2024-07-15
Starting with commercially available 4- or 5-nitropyrazole-3-carboxylic acid, anilides containing nitro, amino or methylsulfonamido were synthesized. Here, manipulation of the substituents on the pyrazole ring was conducted after the anilide formation (). The IC261 of the nitro group was performed
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br Introduction Throughout early prophase I meiotic cells in
2024-07-15
Introduction Throughout early prophase I, meiotic cells intentionally generate DSBs as part of a stringently controlled process to initiate homologous recombination (HR). HR is a critical DSB repair pathway that ultimately permits the exchange of genetic information between homologous chromosomes
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br Mechanisms of GPCR internalization
2024-07-15
Mechanisms of GPCR internalization Like for other types of receptors, prolonged agonist stimulation often leads to GPCR internalization, which can occur via different pathways ∗[2], [20], [21], [22], [23]. Of these pathways, clathrin-mediated Lauric Acid (CME) is the best characterized and argua
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