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For the NSCLC patients with EGFR activating mutations EGFR T
2023-03-16
For the NSCLC patients with EGFR-activating mutations, EGFR-TKIs (gefitinib and erlotinib) are effective clinical therapies [21], [22]. However, approximately 10% of patients harboring EGFR-sensitizing mutations exhibit intrinsic resistance, and up to 40% do not attain a major response to treatment
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br Autophagy and cell death pathways in ischemic stroke Alth
2023-03-16
Autophagy and cell death pathways in ischemic stroke Although very important for the effects on post-ischemic TCS PIM-1 1 synthesis injury, autophagy is not the only mechanism of action involved in cell death. Necrosis and apoptosis are two other distinct forms of cell death with great differenc
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The evidence points toward a
2023-03-16
The evidence points toward a role for 12/15-LO activity in WAT in modulating chronic local inflammation and subsequent systemic metabolic decline in the obese state. However, little is known as to the role of 12- and 15-LOs in BAT. Indeed, in addition to WAT, platelet- and leukocyte-type 12-LO are e
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PD research involves the use
2023-03-16
PD research involves the use of many animal models, which can be categorized into two main types: toxic models—among which the two most widely used are the classical 6-hydroxydopamine (6-OHDA) model in rats and the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model in mice and monkeys—and gen
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The growth of cancer can control
2023-03-16
The growth of cancer can control by inhibiting the rate of cell proliferation or increasing the rate of selective apoptosis and effectiveness of anticancer agents varies according to genetic constitution of cancer. Hence, we investigated the anticancer activity of arginase against different kinds of
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Chlorogenic acid an abundant polyphenol found in coffee and
2023-03-16
Chlorogenic Protease Inhibitor Library receptor (7), an abundant polyphenol found in coffee and the human diet, has various biological activities including antioxidant and anticancer effects [54]. Jiang et al. reported that compound 7 had a selective cytotoxic activity on human oral tumor cells (HS
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br Material and methods br Results br Discussion The present
2023-03-16
Material and methods Results Discussion The present study demonstrates for the first time that Mino selectively induces apoptosis in Jurkat Xifaxan via an H2O2 signaling-dependent mechanism. Structurally, Mino is composed of a C10 and C12 phenol group, C12a hydroxyl group, and C1 and C11 a
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Coincident with APJ receptor several cell types in the body
2023-03-16
Coincident with APJ receptor, several cell types in the body can synthesize apelin protein. For example, the highest apelin concentrations in the body have been found in the rat central nervous system, pituitary gland, lungs, cardiac muscle, gastrointestinal tract and mammary glands, with lower valu
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Thiazole heterocycles constitute an interesting class of mol
2023-03-16
Thiazole heterocycles constitute an interesting class of molecules, which exhibit a broad spectrum of biological activity, including antifungal properties [[16], [17], [18], [19]]. Encouraged by our previous study that describes the activity of hydrazine-thiazole derivatives against C. gattii and C.
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Introduction Cardiovascular disease is the principal cause o
2023-03-16
Introduction Cardiovascular disease is the principal cause of morbidity and mortality in patients with 3ct mg (1). Comprehensive management of these patients includes not only adequate glycemic control but also attention to additional recognized risk factors. Hypertension is a cardiovascular risk
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Most of the modifications in the sympathetic nervous
2023-03-15
Most of the modifications in the sympathetic nervous system occurring with aging, including decreased βAR responsiveness, increased circulating catecholamines, and overall hyposensitivity to adrenergic stress, are also observed in patients with failing hearts. Moreover, young people are more reactiv
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It is reported that Adiponectin
2023-03-15
It is reported that Adiponectin is able to suppress NF-κB pathway, and Bcr-Abl fusion oncoprotein in CML activates NF-κB by stimulating its nuclear translocation and also by enhancing its transactivation function [25], [26]. Therefore, it is tempting to hypothesize that NF-κB pathway might be involv
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Children with ADA SCID commonly suffer from a variety
2023-03-15
Children with ADA-SCID commonly suffer from a variety of opportunistic infections, including viral, fungal, and mycobacterial infections. Due to defects in NMS-1286937 receptor and IG production, they are also susceptible to infection with encapsulated bacteria such as Haemophilus influenzae, Strept
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To date the modes of actions
2023-03-15
To date, the modes of actions of pharmaceuticals in humans and mammals are well-known (Fent et al., 2006), whereas knowledge of aquatic organisms, particularly invertebrates, is limited. This is problematic as these contaminants/pollutants have potentially harmful effects on wildlife organisms that
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Maraviroc The lanthanide series of chemical elements compris
2023-03-15
The lanthanide series of chemical elements comprises the fifteen metallic chemical elements with atomic numbers 57 through 71, from lanthanum to lutetium. Though originally described as ‘‘rare earths’’ because of their natural occurrence as metal oxides, they are not particularly rare. The lanthanid
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