• Although in previous studies by Soldner et al and

  2018-10-22

  

  Although in previous studies by Soldner et al. (2011) and Ding et al. (2013), an initial FACS-based enrichment step of TALEN-expressing ALW-II-41-27 prior to subsequent PCR-based screening of this enriched cell population had to be included, both groups provided initial evidence that the footprintl

• br Conclusions The following are the supplementary

  2018-10-22

  

  Conclusions The following are the supplementary data related to this article. Acknowledgments We thank Drs. Tomoki Todo and Nobuhito Saito of the University of Tokyo, Japan, for generously providing us with the TGS01 cells. This work was supported by Grants-in-Aid for Scientific Research, for

• acetylcholine inhibitor Uchida and co workers performed

  2018-10-20

  

  Uchida and co-workers performed another fate mapping study based on the tet-cre system to chase sca-1–expressing acetylcholine inhibitor and their descendants in the murine heart (Uchida et al., 2013). The authors showed that sca-1 expression is restricted to the non-myocyte compartment and demonstr

• Members of the TGF superfamily TGF or TGF have

  2018-10-20

  

  Members of the TGF-β superfamily, TGF-β1 or TGF-β3, have been shown to induce chondrogenic differentiation (Johnstone et al., 1998; Mackay et al., 1998; Tanaka et al., 2004). In this respect, Lorda-Diez et al. (2011) have performed an elegant in vivo study to identify the temporal hierarchy of the g

• br Engineering cell cell adhesion to

  2018-10-20

  

  Engineering cell–cell adhesion to direct stem cell fate decisions The findings that we described above show that CDH2 and CDH11 play important roles in stem cell lineage specification, and therefore, could be used to develop technologies to control stem cell differentiation by exploiting cell–cel

• Pluripotent stem cell marker analysis iPSCOCT express plurip

  2018-10-20

  

  Pluripotent stem cell marker analysis: iPSCOCT4 express pluripotent markers SSEA3, TRA-1-60, OCT4, NANOG and SOX2 as measured by flow cytometry (Fig. 1E). Pluripotent functionality: iPSCOCT4 are capable of three germ layer differentiation capacity as assessed by in vivo teratoma assay (Fig. 1F).

• Since the analysis of a complete motor unit is essential

  2018-10-20

  

  Since the analysis of a complete motor unit is essential for the understanding of pathophysiological mechanisms of motoneuron diseases (Moloney et al., 2014), or conditions involving the NMJ, we established an in vitro model of motor units. To that end, we cultivated hiPSC cell lines from healthy co

• sphingosine 1-phosphate receptor modulator Using murine ESCs

  2018-10-20

  

  Using murine ESCs, Correa-Cerro et al. (2011) screened the effect of single overexpressed TFs from a panel of 137 transcription factors and selected for those which had the ability to induce a transcriptome shift towards specific lineages at 48h post induction. They followed that report by testing s

• br Materials and methods br Results br Discussion The role

  2018-10-20

  

  Materials and methods Results Discussion The role played by Nurr1 in the regulation of NPCs across several compound library regions has been extensively investigated. It has been suggested that Nurr1 may exert a strong control on both the proliferation and differentiation of NPCs into neur

• br Introduction Capable of almost unlimited proliferation an

  2018-10-20

  

  Introduction Capable of almost unlimited proliferation and efficient differentiation into cardiomyocytes (Yang et al., 2008; Lian et al., 2012; Elliott et al., 2011), hPSCs open a new route for the research of human buspirone hcl development and heart diseases, drug development, and most importa

• Asiatic acid manufacturer br Experimental Procedures br Auth

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments Introduction The defining features of pluripotent stem Asiatic acid manufacturer (PSCs), whether they originate from germ cell tumors, from the embryo, or through cellular reprogramming, are their abilities to undergo self-ren

• Subsequent differentiation of stem cell

  2018-10-20

  

  Subsequent differentiation of stem cell-derived MK progenitors into mature MKs and ultimately platelets has been notoriously difficult. Coculture with OP9 or C3H10T1/2 stroma neurokinin receptor antagonist has been found to greatly facilitate the process (Lu et al., 2011; Takayama et al., 2008), bu

• Previous studies have used acute irradiation induced injury

  2018-10-20

  

  Previous studies have used acute irradiation-induced injury models to provide mechanistic insight into the regeneration process, revealing that actively proliferating IESC (active IESC) and slowly proliferating IESC (quiescent IESC) populations occur within the lower regions of the crypt (Barker et 

• br Introduction Advances in stem cell

  2018-10-20

  

  Introduction Advances in stem-cell-based therapies may help overcome CNS disorders such as spinal cord injury (SCI). Transplantation of neural stem/progenitor gpr120 agonist (NS/PCs) has yielded beneficial effects and improved functional recovery in SCI animal models (Cummings et al., 2005; Hofst

• One difficulty in deriving EpiSCs is the need for

  2018-10-20

  

  One difficulty in deriving EpiSCs is the need for microdissection of small postimplantation embryos. The original protocols used only the epiblast layer separated from the surrounding visceral endoderm (VE) tissue as a source of the cell lines. The overall efficiency of EpiSC derivation from epiblas

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