• Since the analysis of a complete motor unit is essential

  2018-10-20

  

  Since the analysis of a complete motor unit is essential for the understanding of pathophysiological mechanisms of motoneuron diseases (Moloney et al., 2014), or conditions involving the NMJ, we established an in vitro model of motor units. To that end, we cultivated hiPSC cell lines from healthy co

• sphingosine 1-phosphate receptor modulator Using murine ESCs

  2018-10-20

  

  Using murine ESCs, Correa-Cerro et al. (2011) screened the effect of single overexpressed TFs from a panel of 137 transcription factors and selected for those which had the ability to induce a transcriptome shift towards specific lineages at 48h post induction. They followed that report by testing s

• br Materials and methods br Results br Discussion The role

  2018-10-20

  

  Materials and methods Results Discussion The role played by Nurr1 in the regulation of NPCs across several compound library regions has been extensively investigated. It has been suggested that Nurr1 may exert a strong control on both the proliferation and differentiation of NPCs into neur

• br Introduction Capable of almost unlimited proliferation an

  2018-10-20

  

  Introduction Capable of almost unlimited proliferation and efficient differentiation into cardiomyocytes (Yang et al., 2008; Lian et al., 2012; Elliott et al., 2011), hPSCs open a new route for the research of human buspirone hcl development and heart diseases, drug development, and most importa

• Asiatic acid manufacturer br Experimental Procedures br Auth

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments Introduction The defining features of pluripotent stem Asiatic acid manufacturer (PSCs), whether they originate from germ cell tumors, from the embryo, or through cellular reprogramming, are their abilities to undergo self-ren

• Subsequent differentiation of stem cell

  2018-10-20

  

  Subsequent differentiation of stem cell-derived MK progenitors into mature MKs and ultimately platelets has been notoriously difficult. Coculture with OP9 or C3H10T1/2 stroma neurokinin receptor antagonist has been found to greatly facilitate the process (Lu et al., 2011; Takayama et al., 2008), bu

• Previous studies have used acute irradiation induced injury

  2018-10-20

  

  Previous studies have used acute irradiation-induced injury models to provide mechanistic insight into the regeneration process, revealing that actively proliferating IESC (active IESC) and slowly proliferating IESC (quiescent IESC) populations occur within the lower regions of the crypt (Barker et 

• br Introduction Advances in stem cell

  2018-10-20

  

  Introduction Advances in stem-cell-based therapies may help overcome CNS disorders such as spinal cord injury (SCI). Transplantation of neural stem/progenitor gpr120 agonist (NS/PCs) has yielded beneficial effects and improved functional recovery in SCI animal models (Cummings et al., 2005; Hofst

• One difficulty in deriving EpiSCs is the need for

  2018-10-20

  

  One difficulty in deriving EpiSCs is the need for microdissection of small postimplantation embryos. The original protocols used only the epiblast layer separated from the surrounding visceral endoderm (VE) tissue as a source of the cell lines. The overall efficiency of EpiSC derivation from epiblas

• Here we describe the characteristics of

  2018-10-20

  

  Here, we describe the characteristics of a novel SeVdp-iPS vector (SeVdp(KOSM)302L) containing miR-302a target sequences at the 3′-UTR of the L gene. This vector can be used for the efficient reprogramming of MEFs into transgene-free iPSCs without the aid of siRNAs, observed using human embryonic fi

• Expression profiles from tumor tissue and derived cell lines

  2018-10-20

  

  Expression profiles from tumor tissue and derived cell lines are extremely different, thus the current transcriptomic signature for GBM subtyping may not apply in vitro. Using our precursor state signature, we were able to identify an association with the proneural and mesenchymal subtypes. Interest

• As was shown in this study along with many other

  2018-10-20

  

  As was shown in this study, along with many other previous studies, TALEN and double-nicking CRISPR/Cas9 genome-editing techniques are significantly accurate, with only a negligible risk of random gene disruption, in the drug-selected clones. This result indicates that disrupting a particular gene w

• In the present study enzyme activity was dispensable for

  2018-10-20

  

  In the present study, enzyme activity was dispensable for reprogramming and iPSC maintenance. This is in contrast with Fanconi anemia (Raya et al., 2009; Navarro et al., 2014), and also with Sanfilippo type B (Lemonnier et al., 2011) and Pompe disease (Higuchi et al., 2014), in all of which gene com

• The AGM explant culture is

  2018-10-20

  

  The AGM explant culture is known to increase HSC activity. Whether the increase in AGM explant HSCs is due to the expansion and shift in BMP-activation status of existing HSCs, or the new generation of HSCs (non-BMP-activated), or both, remains unclear. Secondary transplantations of GFP+ and GFP− BM

• Rejection might also have occurred as iPSC CMs

  2018-10-20

  

  Rejection might also have occurred as iPSC-CMs might fail to suppress recipient NK APO866 in MHC-matched transplantation. MHC class I molecules such as MHC-E, which are expressed on almost all cells in the body, bind to receptors on NK cells to inhibit cytotoxic activity and, following the immune r

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