• Introduction Human embryonic stem cells hESCs which are deri

  2018-10-22

  

  Introduction Human embryonic stem cells (hESCs), which are derived from the inner cell mass of blastocysts, exhibit unique features including pluripotency, self-renewal and the capacity to differentiate into three germ layers both in vitro and in vivo (Thomson et al., 1998). Several previous studi

• Thus various experimental approaches have been undertaken to

  2018-10-22

  

  Thus, various experimental approaches have been undertaken to determine the exact cellular origin of HSCs in different animal models. Constant cell labeling and time-lapse imaging performed during mouse ESC cultures and BL-CFC development have shown that the hemangioblast generates hematopoietic cel

• br Materials and methods br

  2018-10-22

  

  Materials and methods Conflict of interest statement Acknowledgements This work was supported by the National Natural Science Foundation of China (No. 81070798), Nature Science Foundation of Jiangsu Province (No. BK2009346), Funding Project to Science Facility in Institutions of Higher Lear

• br Materials and methods br Results

  2018-10-22

  

  Materials and methods Results Discussion Currently, a number of cell types such as EPCs, bone marrow mononuclear cells, and mesenchymal stromal pi3k inhibitors are being tested in clinical trials for their efficacy in treating cardiovascular diseases (O\'Neill et al., 2012). Although there

• The following are the supplementary data related

  2018-10-22

  

  The following are the supplementary data related to this article. Disclosure of conflict of interest Acknowledgments We thank Martin Rŭtze for expert help during manuscript revision, Nicole Buchta and Eva-Maria Maurer for technical assistance and the Robert-Mathys Foundation for the donation

• Although in previous studies by Soldner et al and

  2018-10-22

  

  Although in previous studies by Soldner et al. (2011) and Ding et al. (2013), an initial FACS-based enrichment step of TALEN-expressing ALW-II-41-27 prior to subsequent PCR-based screening of this enriched cell population had to be included, both groups provided initial evidence that the footprintl

• br Conclusions The following are the supplementary

  2018-10-22

  

  Conclusions The following are the supplementary data related to this article. Acknowledgments We thank Drs. Tomoki Todo and Nobuhito Saito of the University of Tokyo, Japan, for generously providing us with the TGS01 cells. This work was supported by Grants-in-Aid for Scientific Research, for

• acetylcholine inhibitor Uchida and co workers performed

  2018-10-20

  

  Uchida and co-workers performed another fate mapping study based on the tet-cre system to chase sca-1–expressing acetylcholine inhibitor and their descendants in the murine heart (Uchida et al., 2013). The authors showed that sca-1 expression is restricted to the non-myocyte compartment and demonstr

• Members of the TGF superfamily TGF or TGF have

  2018-10-20

  

  Members of the TGF-β superfamily, TGF-β1 or TGF-β3, have been shown to induce chondrogenic differentiation (Johnstone et al., 1998; Mackay et al., 1998; Tanaka et al., 2004). In this respect, Lorda-Diez et al. (2011) have performed an elegant in vivo study to identify the temporal hierarchy of the g

• br Engineering cell cell adhesion to

  2018-10-20

  

  Engineering cell–cell adhesion to direct stem cell fate decisions The findings that we described above show that CDH2 and CDH11 play important roles in stem cell lineage specification, and therefore, could be used to develop technologies to control stem cell differentiation by exploiting cell–cel

• Pluripotent stem cell marker analysis iPSCOCT express plurip

  2018-10-20

  

  Pluripotent stem cell marker analysis: iPSCOCT4 express pluripotent markers SSEA3, TRA-1-60, OCT4, NANOG and SOX2 as measured by flow cytometry (Fig. 1E). Pluripotent functionality: iPSCOCT4 are capable of three germ layer differentiation capacity as assessed by in vivo teratoma assay (Fig. 1F).

• Since the analysis of a complete motor unit is essential

  2018-10-20

  

  Since the analysis of a complete motor unit is essential for the understanding of pathophysiological mechanisms of motoneuron diseases (Moloney et al., 2014), or conditions involving the NMJ, we established an in vitro model of motor units. To that end, we cultivated hiPSC cell lines from healthy co

• sphingosine 1-phosphate receptor modulator Using murine ESCs

  2018-10-20

  

  Using murine ESCs, Correa-Cerro et al. (2011) screened the effect of single overexpressed TFs from a panel of 137 transcription factors and selected for those which had the ability to induce a transcriptome shift towards specific lineages at 48h post induction. They followed that report by testing s

• br Materials and methods br Results br Discussion The role

  2018-10-20

  

  Materials and methods Results Discussion The role played by Nurr1 in the regulation of NPCs across several compound library regions has been extensively investigated. It has been suggested that Nurr1 may exert a strong control on both the proliferation and differentiation of NPCs into neur

• br Introduction Capable of almost unlimited proliferation an

  2018-10-20

  

  Introduction Capable of almost unlimited proliferation and efficient differentiation into cardiomyocytes (Yang et al., 2008; Lian et al., 2012; Elliott et al., 2011), hPSCs open a new route for the research of human buspirone hcl development and heart diseases, drug development, and most importa

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