• Since BMP secretion in the bone marrow microenvironment

  2018-10-24

  

  Since BMP4 secretion in the bone marrow microenvironment is essential for hematopoietic recovery (Goldman et al., 2009), an inhibitor of BMP4 signaling cannot be used to prevent irradiation-induced BMP4-mediated marrow adipogenesis. Inhibition of PPAR-γ has already been shown to prevent post-irradia

• protein phosphatase Direct cell reprogramming technology is

  2018-10-24

  

  Direct cell-reprogramming technology is based on the dominant action of cell-lineage transcription factors (TFs) in converting adult somatic cells into different cell types (Graf and Enver, 2009). This technique represents a promising avenue in the field of regenerative medicine, with the potential

• Transplantation of iPSC NSCs within the neonatal brain yield

  2018-10-24

  

  Transplantation of iPSC-NSCs within the neonatal jasplakinolide yielded stable engraftment across the neuroaxis for at least 4 months, but only within and adjacent to white matter tracts. Although the precise mechanisms are unclear, NSCs from various sources display a tropism for white matter in bo

• br Acknowledgements This work was supported by the

  2018-10-24

  

  Acknowledgements This work was supported by the IRET Foundation (2015-2016), Ozzano Emilia, Italy (no-profit organization), in the frame of the “Step-by-step” POR-FESR 2016-2020 Emilia Romagna Region project. Introduction Resident neural stem cells (NSCs) persist in the adult mammalian centr

• Existing treatments for myelomeningocele repair consist of p

  2018-10-24

  

  Existing treatments for myelomeningocele repair consist of pre- or post-natal surgical closure of the defect. Prenatal intervention has been shown to be more effective than postnatal surgery because it can prevent or ameliorate sequels (Adzick et al., 2011; Adzick et al., 1998; Meuli et al., 1997; M

• In addition to studying drug effects on AP and

  2018-10-24

  

  In addition to studying drug effects on AP and calcium handling, we also showed the potential of using genetic reporters for studying inherited arrhythmogenic disorders. To this end, we utilized a previously established LQTS2 patient-specific line (Itzhaki et al., 2011a) and also generated a new hiP

• Importantly because none of these markers are

  2018-10-24

  

  Importantly, because none of these markers are specific for trophoblast or trophoblast populations in general, they must be used in combination. For example, SWAN-71 and HTR8/SVneo, two widely used “trophoblast” cell lines, are hypermethylated at the ELF5 promoter, HTR8/SVneo does not express C19MC

• br Results br Discussion We have successfully established a

  2018-10-24

  

  Results Discussion We have successfully established a human stem cell model to study the molecular mechanisms underlying MODY5. Our experimental design, which includes a non-family control hiPSC line and three independent hiPSC lines from each of the three subjects in a MODY5 family, is a well

• cyclooxygenase pathway Previous reports have described ESC b

  2018-10-24

  

  Previous reports have described ESC-based differentiation in collagen gels to study the developmental events of vasculogenesis and angiogenesis (Feraud et al., 2001; Hermant et al., 2007). However, these were not optimized for the assessment of more fundamental aspects of vessel induction, patternin

• We provide evidence that RUNX has a role in

  2018-10-24

  

  We provide evidence that RUNX1 has a role in early mesendodermal differentiation of hESCs through regulation of cell migration and adhesion, as indicated by impairment of these processes upon RUNX1 depletion. These findings are consistent with the emerging role of RUNX1 in controlling cell motility

• Microcephaly is a neurodevelopmental disorder where the head

  2018-10-24

  

  Microcephaly is a neurodevelopmental disorder where the head is smaller than the typical size during fetal development and at birth, with the circumference less than 2 SDs below the mean (Centers for Disease Control and Prevention, 2016b). Babies with microcephaly can have a wide array of problems s

• Stem cell research and the

  2018-10-24

  

  Stem cell research and the ISSCR have undergone enormous growth over the past 15 years, as evidenced by the strength of basic research programs, industry, and clinical trials that are pioneering the field of regenerative medicine. As the ISSCR celebrates its milestone 15th anniversary, we ask for yo

• br Experimental Thiophene aniline and titanium chloride TiCl

  2018-10-24

  

  Experimental Thiophene, aniline and titanium chloride (TiCl4) were purchased from SD fine, India. AR grade were used as starting chemicals, without further purification. The TiCl4 was used as an oxidizing agent to initiate the chemical polymerization. The random copolymer of PTh-co-PANI-Ti was sy

• adrenergic receptors The existence of similar charged partic

  2018-10-24

  

  The existence of similar charged particle trajectories in these fields due to the property of homogeneity allows to create analyzers with multi-channel registration of charged particles with respect to energy (electric spectrographs) or mass number (magnetic spectrographs). In the last 10 years, a n

• To our knowledge there is no

  2018-10-24

  

  To our knowledge there is no research investigating whether the association between SRH and mortality differs across regions in the United States. Yet the question of regional variation in the mortality predictive validity of SRH is a central one. If the relationship between SRH and mortality varies

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