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Based on these considerations and the presented
2018-11-05
Based on these considerations and the presented microbiological and clinical observations, we decided to stop the PT trial at interim analysis. In summary, while phage therapy is still one very important alternative tool against antibiotic resistance, we need to understand in detail the in vivo inte
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Previous work showed that lncRNAs show higher tissue
2018-11-05
Previous work showed that lncRNAs show higher tissue specificity compared to mRNAs (). The work of Ching et al. supported this notion, and extended it by showing a reduction of specificity after malignant transformation, which is consistent with the de-differentiation status of cancers widely observ
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The pooled results indicate relatively low diagnostic
2018-11-05
The pooled results indicate relatively low diagnostic sensitivity of 0.70, and specificity of 0.83, suggesting a relatively high rate of missed diagnoses (30%) and misdiagnoses (17%). Likelihood ratios >10 and mtor pathway from BALF correlates well with results from conventional immunocytochemistry
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fak inhibitor br Detection of cancer by analysis of circulat
2018-11-05
Detection of cancer by analysis of circulating cell-free DNA (cfDNA) has received enormous attention over the past years (). cfDNA is released into the blood circulation by apoptotic and necrotic cells, and cancer patients have increased concentrations of cfDNA (). With the development of novel te
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Tenofovir alafenamide TAF National Center
2018-11-05
Tenofovir alafenamide (TAF) (National Center for Biotechnology Information, n.d.-b, CID=9,574,768) is a prodrug of TFV that is more stable in plasma, allowing for a ten-fold reduction in dose and resulting in a 91% reduction in gpr40 agonist TFV while achieving a four-fold increase in intracellular
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Tenofovir alafenamide TAF National Center
2018-11-05
Tenofovir alafenamide (TAF) (National Center for Biotechnology Information, n.d.-b, CID=9,574,768) is a prodrug of TFV that is more stable in plasma, allowing for a ten-fold reduction in dose and resulting in a 91% reduction in ampk inhibitors TFV while achieving a four-fold increase in intracellul
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br The Multibiome Importance of Individual Groups Mammalian
2018-11-05
The Multibiome: Importance of Individual Groups Mammalian physiology has undergone evolutionary optimization in collaboration with the bacterial microbiome, as illustrated by the physiologic defects that have been described in germ-free (GF) animals, including impaired intestinal function, immune
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Stattic Treating Age related Macular Degeneration Using Huma
2018-11-05
Treating Age-related Macular Degeneration Using Human iPS Cells Age-related macular degeneration (AMD) is a medical condition of the eye that results in blurred vision and/or a loss of central vision. The wet form of AMD – caused by abnormal blood vessel growth – is often treated using anti-VEGF me
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br Conclusion Various researchers have developed computer ba
2018-11-05
Conclusion Various researchers have developed computer-based DSSs for the management and operation of reservoirs and river systems. Russell and Campbell (1996) reported that these focused primarily on the physical aspects of the system. They are frequently based on simple engineering principles f
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Using independent spatial descriptions for solving the forwa
2018-11-05
Using independent spatial descriptions for solving the forward problem and doing the inversion step raises the following challenge. Not only need information to be transferred from the external forward codes into ASKI (as described above), but also information about the new model derived in an itera
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Adan and Natale in a study conducted in Barcelona involving
2018-11-05
Adan and Natale (2002), in a study conducted in Barcelona involving 2135 individuals with age between 17 and 30 years, verified association between the male gender and eveningness [40]. In the same year, in Brazil, Hidalgo et al. (2003) investigated 318 individuals of the same age, obtaining the sam
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Sleep fragmentation persists in many patients with
2018-11-05
Sleep fragmentation persists in many patients with insomnia despite an adequate insomnia treatment. The sleep fragmentation associated with UARS can cause daytime fatigue and enhance anxiety, factors that can increase the difficulty in treating chronic insomnia. Postmenopausal women with chronic ins
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In this scenario the relationship
2018-11-05
In this scenario, the relationship between exhausting physical effort and musculoskeletal pain may be one of the possible explanations for the findings concerning predictors of risk for sleep disturbances among the workers studied. This is particularly true for rubber tappers, providing an intriguin
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glut1 To establish the sensor s specificity
2018-11-05
To establish the sensor’s specificity and reproducibility for Hg2+ detection in the field, the response to other potential contaminants must be minimized. The sensor was tested with a variety of other ions, including common environmental contaminants, e.g., Na+, Fe3+, Ca2+, Pb2+, and Cd2+ with the s
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Introduction Microelectrode arrays MEAs are substrate
2018-11-05
Introduction Microelectrode arrays (MEAs) are substrate-integrated extracellular electrode matrices kept in contact with Fmoc-His(Trt)-OH in culture. MEA-based cell electronic interfaces enable the study of neuronal network processes, the evaluation of the effects of drugs and the electrophysiologi
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